What learning a good new knot does is it allows you to run new advances in line technology reliably. Lines have changed dramatically in the last 25 years. Before spectra I ran 20 lb mono on my mainline and lost a lot of fish to seals, and a lot of gear on bottom. I was a very early adopter of spectra for Salmon fishing. Using spectra required learning new knots to connect it to Mono. I learnt the Albright Special for mono to spectra connections and have never looked back. Using spectra on my salmon gear now with heavier test main and leaders I hardly ever lose fish to seals or bottom. I release a lot of my salmon, and the new lines allow me to play the fish quickly, and not exhaust a fish that I'm going to release. If I see a seal or sea lion after my fish these new lines have allowed me to horse the fish in quickly before it gets a hold of it. I also prefer the feel of a battle on spectra (with a top shot of mono for some cushion). Spectra line with very good knots also has allowed me to fish far deeper with little gear loss when targeting bottom species.
Using all these great advances in line technology would never have been possible without learning new knots. The knots I used before spectra are totally different than what I use now. The deep sea fishing forums are great places for finding out the most recent developments in reliable connections to use. That's where I got the idea of running a mono top shot from and learned about the using the Albright Special knot. I was one of the first guys to start spreading the word about running a top shot with an Albright knot version on the forum. Next to no one was using that setup here at that time. The term "Top Shot" wasn't even known in these parts back then. Now it is commonly used in BC for Salmon fishing. I have never had a knot failure using the Albright Special for my top shot connection in many years of use. It took a bit of knot experimentation before I settled on that knot for joining mono to spectra. Without learning a knot with 100% strength and reliability, joining spectra to mono is pure folly. Learning new knots is a pain, but you will be left using old technology, (or have knot failures) if you don't tailor your knot specifically to the type of new lines being constantly developed.
Using spectra on my Downrigger I use loop knots that I found online at spectra line kite fishing sites. New knots are being developed all the time, and the Internet allows them to be spread all over the world. Searching them out takes a little extra time and effort, but it pays big dividends in gear reliability. I can honestly say I can't remember the last time a seal out battled me for a fish since switching to these lines and knots. I only had one Salmon taken by a seal this season. It was a spring about 22 lbs, and I beat the seal with no problems using my heavy test setup with good connections. The other advantage to using this type of setup is when a large Halibut is unexpectedly hooked while trolling for Salmon. I've had no problems landing Halibut on my Salmon gear when I've been lucky enough to catch them when trolling for Salmon.
Flourocarbon knots require an even different set of knots from mono to maximize strength, (and minimize knot failures). I'm still looking for just the right knot for fluorocarbon. I've started further research on the best ones to use recently. Maybe this version of the Improved Trilene Knot will prove to be the knot I settle on for tying Flouro. If not, I'll just keep searching for the best knot for every line application. No one knot serves well for everything. The strongest of knots used for years in mono, might actually be a very poor knot choice for spectra or Flouro. Even the same knot that will work well on lighter lines in a specific line class, may be a very poor choice for large test lines with the same knot. One knot does definitely not fit all applications. Learning new knots is the best way to be able to use new advances in line technology. Line and gear changes all the time, and experimenting with new innovations is one of my favorite things about fishing. There's a lot of great new stuff on the Internet coming out almost daily. You may find new stuff you actually prefer and are way more effective at catching fish, if you're willing to do a little experimentation.